Weird Long-Term Side Effects of Chemotherapy

Breast cancer treatment, particularly chemotherapy, is a vital component of the journey toward recovery. It’s a testament to your strength and resilience as you face the challenges head-on. However, it’s essential to recognize that, while chemotherapy can be highly effective, it may also come with long-term side effects. At Twins4wellness, we believe in comprehensive support for every stage of your wellness journey. In this blog post, we’ll explore some of the potential weird long-term side effects of chemotherapy in breast cancer treatment and offer insights on managing them.

In this picture I am under going chemotherapy for breast cancer. I didn't realize at the time that there would be weird long-term side effects from the Chemotherapy.
In this picture, I am undergoing chemotherapy for breast cancer. I didn’t realize at the time that there would be weird long-term side effects from the Chemotherapy.

Weird Long-Term Chemotherapy Side Effects

1. Cognitive Changes:

Many individuals who undergo chemotherapy experience what’s commonly known as “chemo brain.” This term refers to cognitive changes such as memory issues, difficulty concentrating, and mental fogginess. These effects can be frustrating, but it’s important to understand that they are often temporary. Engaging in mental exercises, maintaining a healthy lifestyle, and seeking support from healthcare professionals can improve cognitive function over time. Here is a link to a post about chemo brain: Important Ways to Cope with Debilitating Chemo Brain.

2. Fatigue:

Fatigue is a common long-term side effect of chemotherapy. It can persist for weeks, months, or even longer after treatment. Listen to your body and prioritize rest when needed. Gentle exercise, proper nutrition, and staying hydrated can also help manage fatigue. I am still tired all the time, even months after treatment.

3. Peripheral Neuropathy:

Some individuals may experience peripheral neuropathy, which is characterized by numbness, tingling, or pain in the hands and feet. Communicating any symptoms to your healthcare team is crucial, as they can help manage and alleviate this discomfort. My doctor said the neuropathy can show up any time after chemotherapy. I had some minor neuropathy in my hands and feet but it went away after I was done with chemotherapy. I still have tingling in my upper thighs, 8 months later, that my oncologist says was from the chemo.

woman in black long sleeve shirt sitting on brown wooden chair
Photo by cottonbro studio on Pexels.com

4. Emotional Well-being:

Chemotherapy can take a toll on your emotional well-being. Feelings of anxiety, depression, or mood changes are not uncommon. Seeking emotional support from therapists, support groups, or trusted friends and family can make a significant difference in managing these feelings. I joined a support group online and it was very nice to be able to talk to other women who went through similar experiences. I highly recommend joining a breast cancer support group.

5. Heart Health:

Certain chemotherapy drugs, while effective against cancer, may have an impact on heart health in the long term. It’s essential to maintain regular check-ups with your healthcare provider, particularly if your treatment involves drugs with potential cardiac effects. Adopting a heart-healthy lifestyle with proper diet, exercise, and stress management is crucial.

6. Bone Health:

Chemotherapy may affect bone health, increasing the risk of osteoporosis or bone fractures in the long run. Discuss bone health strategies with your healthcare team, which may include calcium and vitamin D supplementation, weight-bearing exercises, and periodic bone density assessments.

woman practicing yoga
Photo by Elina Fairytale on Pexels.com

7. Fertility:

For younger individuals, chemotherapy may impact fertility. It’s crucial to have open discussions with your oncologist about fertility preservation options before starting treatment. If fertility is a concern, consider seeking consultation with a reproductive specialist.

8. Risk of Secondary Cancers:

While chemotherapy reduces the risk of cancer recurrence, there’s a slight increase in the risk of developing secondary cancers in the long term. Regular follow-up appointments and screenings are essential to catch any potential issues early.


Understanding the potential long-term side effects of chemotherapy in breast cancer treatment empowers you to manage your health and well-being proactively. It’s essential to communicate openly with your healthcare team, adopt a healthy lifestyle, and seek support from your loved ones and professionals. At Twins4wellness, we believe that with the right care, resources, and a positive mindset, you can navigate these challenges and continue your journey toward lasting wellness.


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